O le Phosphorylation e a'afia ai vaega uma o le ola feavea'i, ma o le protein kinases e a'afia ai vaega uma o galuega tau feso'ota'iga i totonu o le tino e ala i le fa'atonutonuina o ala fa'ailo ma fa'agaioiga feavea'i.Ae ui i lea, o le aberrant phosphorylation o le mafuaʻaga foi lea o le tele o faʻamaʻi;aemaise lava, mutated protein kinases ma phosphatases e mafai ona mafua ai le tele o faʻamaʻi, ma le tele o toxins masani ma pathogens e iai foi se aafiaga e ala i le suia o le tulaga phosphorylation o polotini intracellular.
O le Phosphorylation o serine (Ser), threonine (Thr), ma tyrosine (Tyr) o se faʻagasologa o suiga ole polotini e mafai ona faʻaaogaina.O loʻo aʻafia i latou i le faʻatonutonuina o le tele o gaioiga feaveaʻi, e pei o le faʻailoga o le tali, faʻatasiga porotini ma le vaeluaina, faʻagaoioia poʻo le faʻasaina o galuega faʻapolotini, ma e oʻo lava i le ola ola.Phosphates e leaga le tauina (lua tau leaga ile vaega phosphate).O le mea lea, o la latou faʻaopoopoga e suia ai mea totino o le polotini, lea e masani lava o se suiga faʻavae, e oʻo atu ai i se suiga i le fausaga o le porotini.A aveese le vaega o le phosphate, o le a toe foʻi le faʻatulagaina o le polotini i lona tulaga muamua.Afai e fa'aalia e polotini fa'atusa e lua ni gaioiga eseese, e mafai ona galue le phosphorylation e fai ma sui mole mole mo le polotini e pulea ai lana gaioiga.
O le tele o hormones e faʻatonutonu le gaioiga o enzymes faʻapitoa e ala i le faʻateleina o le phosphorylation state o serine (Ser) poʻo le threonine (Thr) toega, ma tyrosine (Tyr) phosphorylation e mafai ona faʻaosoina e mea faʻatupulaia (pei o le inisalini).O vaega phosphate o nei amino acids e mafai ona vave aveese.O le mea lea, o Ser, Thr, ma Tyr o loʻo galue e fai ma sui mole mole i le faʻatonutonuina o gaioiga feaveaʻi e pei o le faʻateleina o le tuma.
O peptides fa'aola e faia se sao aoga tele i le su'esu'eina o le protein kinase substrates ma fegalegaleaiga.Ae ui i lea, o loʻo i ai nisi mea e faʻalavelaveina pe faʻatapulaʻaina le fetuutuunai o le phosphopeptide synthesis technology, e pei o le le mafaia ona ausia atoa le faʻaogaina o le solid-phase synthesis ma le leai o se fesoʻotaʻiga talafeagai ma faʻamaumauga masani suʻesuʻe.
O le faʻavae faʻavae peptide synthesis ma le phosphorylation modification technology e faʻatoʻilaloina nei tapulaʻa aʻo faʻaleleia le faʻaogaina o le faʻaogaina ma le faʻalauteleina, ma e fetaui lelei le faʻavae mo le suʻesuʻeina o protein kinase substrates, antigens, fusifusia mole, ma inhibitors.
Taimi meli: Me-31-2023