folasaga
Gorelatide, e lauiloa foi o le n-acetyl-serine - aspartic acid - proline - proline - (N-Acetyl-Ser-Asp-Lys-Pro), faʻapuʻupuʻu o le Ac-SDKP, o se tetrapeptide endogenous, nitrogen end acetylation, faʻasalalau lautele i totonu. aano eseese ma sua o le tino i totonu o le tino.O lenei tetrapeptide e faʻasaʻolotoina e le prolyl oligopeptidase (POP), lea e mafua mai i lona thymosin muamua.Ole maualuga ole toto e masani lava ile fua ole nanomole.
okinetics
E tusa ai ma suʻesuʻega pharmacokinetic a Gorelatide, pe a maeʻa le tui tui, Gorelatide vave faʻaleagaina ma le afa-ola e na o le 4 ~ 5min.Gorelatide e faʻamamaina mai le plasma tagata e ala i auala e lua:①Angiotensin-faaliliuina enzyme (ACE) -taʻitaʻia hydrolysis;②Glomerular filtration.Ole hydrolysis ole angiotensin converting enzyme (ACE) ole auala autu ole metabolism gorelatide.
Gaoioiga olaola
O le Gorelatide o se ituaiga o mea fa'atonutonu fa'alesoifua maloloina fa'apitoa fa'atasi ai ma gaioiga fa'aletino eseese.Na lipotia muamua e mafai e le Gorelatide ona taofia le ulufale atu o sela muamua o le hematopoietic stem i le vaega S ma faʻamautu i latou i le vaega G0, faʻalavelaveina le gaioiga o sela hematopoietic stem.Na maua mulimuli ane e mafai e le Gorelatide ona faʻaleleia le gafatia o le toe totoina o le epidermal e ala i le faʻaleleia o le faʻavaeina o vaʻa toto ma faʻavavevave le faʻamalolo o manuʻa i faʻamaʻi vascularized epidermal grafts.Gorelatide e mafai ona faʻalavelaveina le eseesega o sela o le gaʻo ponaivi e faʻaosofia e le MGM i macrophages, ma faʻapea ona taʻalo ai se matafaioi anti-inflammatory.Gorelatide talu ai nei na maua e taofia ai le faʻateleina o sela eseese.
fa'aoga
I le avea ai o se polypeptide organic matter, e mafai ona faʻaaogaina le Gorelatide e fai ma vailaʻau.
Taimi meli: Apr-26-2023