Va'aiga lautele ma le fa'aogaina o le cerulein

Vaaiga lautele

Caerulein, e ta'ua fo'i o le cerulein, ose pa'u mai le rane Ausetalia HYlacaerulea e aofia ai le 10 amino acids.O se mole mole decapeptide e tuʻuina atu e le trifluoroacetate lea e galue o se cholecystokinin analog i luga o sela vesicular pancreatic ma e mafai ona taʻitaʻia ai le faʻaogaina o se numera tele o enzymes digestive ma sua pancreatic, e mafua ai le edematous pancreatitis.Cerutin e mafai ona faʻaaogaina e suʻesuʻe ai le Nf-κb up-regulation proteins e pei ole intercellular adhesion molecule-1 (ICAM-1) faʻafitauli e fesoʻotaʻi ma le mumū e pei ole NADPH oxidase ma Janus kinase faʻasalalau faʻasalalauga faʻasalalauga.Ua fa'aaogaina ma le manuia e fa'avae ai fa'ata'ita'iga o le ma'i ma'i pancreatitis i isumu, isumu, ta'ifau, ma le hamsters a Suria (AP).E sili ona lelei le tu'iina o vai i totonu o le toto e ala i tui toto, dermal, po'o le intraperitoneal.E faʻaaogaina lautele i suʻesuʻega faʻataʻitaʻi o le maʻi edematous pancreatitis, ma faʻataʻitaʻiga in vitro e faʻaaogaina i faʻataʻitaʻiga sela.E le gata i lea, e faʻaaogaina mo suʻesuʻega o gallbladder.

Va'aiga lautele ma le fa'aogaina o le cerulein

Fa'amatalaga auiliili

Fa'aaliga: pa'epa'e pa'epa'e

Numera CAS: 17650-98-5

Gutuo Nu. : GT-F055

Fa'asologa: pGlu-Gln-Asp-Tyr(SO3H)-Thr-Gly-Trp-Met-Asp-Phe-NH2

fua mole: C58H73N13O21S2

mamafa mole: 1352.4

Solubility: Fa'amuta i le 50mM ammonium hydroxide ile fa'atonuga ole 1.0mg/ml

Fa'atatauga

1. E faʻaaogaina lautele i le faʻataʻitaʻiina o le maʻi edematous pancreatitis i faʻataʻitaʻiga falemaʻi.

2. Fa'aoga i fa'ata'ita'iga sela i vitro.

3. Fa'aaogaina mo su'ega gallbladder.

Le atinaʻeina o se faʻataʻitaʻiga mo le suʻesuʻeina o le pancreatitis acute mo le suʻesuʻeina o le cerulein (AP) cell biology, pathophysiological uiga ma faʻaaliga o faʻamaʻi faʻamaʻi i le maʻi pancreatitis.I le faaopoopo atu i le suʻesuʻeina o suiga ole pulmonary o le maʻi AP, e mafai foi ona faʻaalia lelei le fesoʻotaʻiga visceral endocrine e pei ole maualuga ole metabolin ma le CCK.E mafai fo'i ona fa'aoga e iloilo ai le toe fa'aleleia ma le toe fa'aleleia o a'ano manu'a pe a uma ona fa'amutaina mea mata'utia.

5. Faʻaaogaina o le Caerulein cerulein (cerulein) ma le LPS e faʻavaeina ai faʻataʻitaʻiga pancreatitis e mafai ona maua ai aʻafiaga synergistic, o le mea muamua e mafai ona faʻaosofia ai enzymes pancreatic e faʻaumatia ai le pancreas, ma faʻaauau pea ona faʻagaoioia sela inflammatory e faʻasaʻo ai mea inflammatory.Mulimuli ane, o le LPS e faʻalavelaveina le tali masani a tagata faufautua faʻamaʻi, ma faʻapupulaina ai le pancreatitis faʻapitonuʻu e avea o se faʻalavelave faʻalavelave matuia.

6. Cerulein e mafai ona faʻaaogaina e puipuia ai le tiga o le gallbladder, colic renal, ma le tiga o le claudication le tumau.E masani ona manatu o se mea fa'ato'aga kephalin endogenous.